TACE and apatinib combined with camrelizumab for treating giant hepatocellular carcinoma
10.13929/j.issn.1672-8475.2025.05.002
- VernacularTitle:TACE联合阿帕替尼及卡瑞利珠单抗治疗巨块型肝细胞癌
- Author:
Jie JI
1
;
Di ZHU
;
Yuguan XIE
;
Fu'an WANG
;
Penghua LYU
;
Weizhong ZHOU
;
Lele YAN
Author Information
1. 苏北人民医院介入放射科,江苏 扬州 225001
- Publication Type:Journal Article
- Keywords:
carcinoma,hepatocellular;
tumor burden;
chemoembolization,therapeutic;
antineoplastic agents;
treatment outcome
- From:
Chinese Journal of Interventional Imaging and Therapy
2025;22(5):310-314
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy and safety of TACE and apatinib combined with camrelizumab for treating giant hepatocellular carcinoma(HCC).Methods Totally 78 patients with giant HCC were retrospectively collected,including 22 cases received TACE and apatinib combined with camrelizumab(TACE+AC group)and 56 cases received TACE and apatinib(TACE+A group).Propensity score matching analysis was used to select 44 cases(TACE+A'group)from TACE+A group who were matched to those in TACE+AC group at 1:2 ratio.The overall survival(OS),progression-free survival(PFS)and the adverse events were recorded and compared among groups.Results Patients in TACE+AC group had a median OS of 17.8(95％CI:17.5-18.1)months and a median PFS of 8.8(95％CI:5.4-12.3)months,which in TACE+A'group was 9.8(95％CI:7.6-12.1)months and 5.5(95％CI:2.7-8.3)months,respectively.The overall OS rate and PFS rate in TACE+AC group were significantly higher than those in TACE+A' group(both P<0.05).The incidences of thyroid dysfunction,immune pneumonia and reactive cutaneous capillary endothelial proliferation in TACE+AC group were significantly higher than those in TACE+A' group(all P<0.05).No death associated with adverse events occurred.Conclusion Compared with TACE and apatinib,further combining with camrelizumab could get better survival benefit for giant HCC patients with acceptable adverse events.
