Research progress on intestinal macrophages in inflammatory bowel disease
10.3760/cma.j.cn101480-20240122-00016
- VernacularTitle:肠道巨噬细胞在炎症性肠病中的研究进展
- Author:
Xuan BU
1
;
Chunbao ZHAI
Author Information
1. 山西医科大学第五临床医学院，太原 030012
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Macrophages;
Exosomes;
Intestinal flora;
Ubiquitination;
Deubiquitination;
Immune metabolism;
Autophagy
- From:
Chinese Journal of Inflammatory Bowel Diseases
2025;09(1):84-89
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a refractory chronic inflammatory disease of the intestine, and its etiological mechanism is still unclear. Recent studies have shown that the intestinal macrophages participates the intestinal immunity by regulating exosomes, intestinal flora, ubiquitination and deubiquitination, immune metabolism and autophagy, plays an important role in maintaining intestinal homeostasis, and is closely related to the occurrence and development of IBD. Investigating the underlying mechanisms of macrophages in IBD advancement may provide new therapeutic approaches. This article reviews the latest research progress on the multifaceted mechanisms of intestinal macrophages in IBD.
