Mechanism of action and application prospect of Akkermansia. muciniphila in inflammatory bowel disease
10.3760/cma.j.cn101480-20240306-00033
- VernacularTitle:嗜黏蛋白阿克曼菌在炎症性肠病中的作用机制及应用前景
- Author:
Dan LI
1
;
Jun ZHANG
1
Author Information
1. 南京医科大学附属南京医院（南京市第一医院）消化科，南京 210006
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Akkermansia. muciniphila;
Mechanism
- From:
Chinese Journal of Inflammatory Bowel Diseases
2025;09(1):80-83
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of inflammatory bowel disease (IBD) is complex, including multiple factors such as genetic predisposition, environmental factors, intestinal microbiota disorders, epithelial barrier dysfunction, and immune system dysregulation. Among these factors, the gut microbiome plays an important role. Notably, Akkermansia. muciniphila is an intestinal bacterium potentially associated with IBD. This review summarizes the mechanism of action of Akkermansia. muciniphila in IBD, including strengthening the intestinal barrier, modulating inflammatory responses, interacting with the gut microbiome, and its potential in IBD treatment. Additionally, the strain specificity and safety of Akkermansia.muciniphila are also discussed.
