Meta analysis of efficacy of citalopram combined with risperidone in the treatment of refractory depression
10.3760/cma.j.issn.1009-6906.2017.05.014
- VernacularTitle:西酞普兰联合利培酮治疗难治性抑郁症疗效评价的Meta分析
- Author:
Ling LI
1
;
Zhenzhen FAN
;
Hongbin CAI
;
Yu YANG
;
Zhaoming GE
Author Information
1. 兰州大学第二医院心理卫生科, 兰州,730000
- Publication Type:Journal Article
- Keywords:
Citalopram;
Risperidone;
Refractory depression;
Meta analysis;
Randomized controlled trials
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2017;24(5):394-398
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate comprehensively the efficacy and safety of citalopram combined with risperidone in the treatment of refractory depression.Methods Computer-aided information retrieval was made by using such databases as PubMed,Cochrane Library,Embase,CBM,CNKI,VIP,WanFang and Lancet as well,at the same time,manual data retrieval was also made by searching related literature from both published and unpublished papers,and both at home and abroad.The time span for information retrieval was from the inception to December 2016.After 2 reviewers screened independently the retrieved literature in accordance with the included and excluded selection criteria,and collected the retrieved papers and evaluated methodological the quality of the retrieved literature,meta-analysis was performed by using RevMan 5.3 software.Results Finally,a total of 8 randomized controlled trials (RCTs) involving 711 patients were included in the study.Meta-analyses showed that the effective rate and cure rate of the citalopram combined with risperidone group were respectively [OR =3.47,95％ CI (2.33,5.16)] (P ＜ 0.01) and [OR =2.48,95％CI (1.64,3.76)] (P ＜0.01),which were superior to those of the simple citalopram group.Following treatment of 2,4,6 and 8 weeks,HAMD scores of the experimental group were respectively [SMD =0.65,95％CI (0.39,0.92),P ＜0.01;SMD =0.59,95％ CI (0.34,0.84),P ＜0.01;SMD =0.62,95％ CI (0.24,0.99),P =0.001;SMD =0.78,95％ CI (0.27,1.29),P =0.003].After treatment of 2,4 and 6 weeks,HAMA scores of the experimental group were respectively[SMD =0.51,95％ CI (0.09,0.92),P =0.02;SMD=0.34,95％CI (0.09,0.58),P=0.007;SMD=0.54,95％CI (0.15,0.93),P=0.007],which were also superior to those of the simple citalopram group.Following treatment of 4 and 6 weeks,TESS scores of the experimental group were respectively [SMD =-0.37,95％ CI (-1.66,0.92),P =0.580;SMD =-0.19,95％ CI (-0.90,0.51),P =0.590].There was no statistical significance when comparisons were made between the 2 groups.Conclusions Current evidence shows that citalopram combined with risperidone could produce good effects on refractory depression,without obvious adverse reactions.For this reason,risperidone could be supplemented clinically,so as to enhance therapeutic efficacy in the treatment of refractory depression.
