A primary research on the effect and safety of low frequency repetitive transcranial magnetic stimulation over the left orbitofrontal cortex in patients with obsessive-compulsive disorder
10.3760/cma.j.issn.1006-7884.2018.06.007
- VernacularTitle:左眶额皮质低频重复经颅磁刺激治疗强迫症的初步研究
- Author:
Si MI
1
;
Xiangyun YANG
1
;
Danna ZHOU
1
;
Yujuan WANG
1
;
Yanping REN
1
;
Zhanjiang LI
1
Author Information
1. 100088,首都医科大学附属北京安定医院国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Transcranial magnetic stimulation;
Treatment outcome;
Onset time
- From:
Chinese Journal of Psychiatry
2018;51(6):373-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective To primarily explore the efficacy,onset time and safety of low frequency repetitive transcranial magnetic stimulation (rTMS) over the left orbitofrontal cortex (LOFC) on obsessive-compulsive disorder(OCD).Methods Twenty-four OCD patients were randomly assigned into 2 groups,one group (n＝12) with sertraline and rTMS,the other group (n＝12) with sertraline and sham rTMS.The stimulus parameter was 80～-110～ motor threshold,1 Hz,5 sessions per week.The efficacy was assessed by using Y-BOCS,HAMD and HAMA at base line,2,4 and 6th week after treatment,and the safety by recording Adverse Event and Severe Adverse Event.Results The scores of Y-BOCS(F＝23.401,P＜0.01),obsession(F＝23.516,P＜0.01),compulsion (F＝15.025,P＜0.01),HAMD (F＝7.23,P＜0.01) and HAMA (F＝8.389,P＝0.002) of 2 groups all significantly decreased after 6 week treatment,but there was no significant differences between 2 groups.The effective rate of the two groups was statictically different (Fisher test,P＝0.030),and the remission rate was not statistically different (Fisher test,P＝0.183).The Y-BOCS scores in the sertraline + rTMS group at 2 week treatment (23.0 ± 5.1 vs.18.1 ± 5.7) were statistically different from the baseline(LSD test,P＝0.005),but the sertraline + sham rTMS group did not show a statistically significant difference(LSD test,P＝0.025) until 4 weeks after treatment (24.4±4.3 vs.17.6±7.3).The occurrence rates of adverse events were not statistically different among 2 group (all P＞0.05).No severe adverse events happened.Conclusions Low frequency rTMS over the LOFC combined drug may have potential advantages in OCD with faster effect than drug.But the finding needs to be verified in large sample with randomized controlled trials.
