Significance of fungus-bacterium homeostasis in inflammatory bowel disease
10.3760/cma.j.cn101480-20230906-00016
- VernacularTitle:肠道真菌-细菌稳态在炎症性肠病中的意义
- Author:
Siyuan CHEN
1
;
Qunyan ZHOU
1
;
Jing SUN
1
;
Xinwen XU
1
;
Zhongxia CHEN
1
;
Fangmei AN
1
;
Qiang ZHAN
1
Author Information
1. 南京医科大学附属无锡人民医院消化内科 南京医科大学无锡医学中心，无锡 214023
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Fungus;
Bacterium;
Intestinal microecology
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(4):314-318
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a group of digestive tract diseases characterized by chronic intestinal inflammation, including ulcerative colitis and Crohn′s disease. The over-sustained immune response driven by imbalance of intestinal microbiota plays a key role in the initiation and progression of IBD. Studies have identified that intestinal microbiome possesses more than a hundred trillion types, including bacteria and fungi, which collectively participates in energy metabolism, intestinal barrier function and immune balance. There exists a stable relationship between fungi and bacteria in the intestine, involving cooperation, antagonism, and mutualism. Fungus-bacterium homeostasis plays an important role in maintaining intestinal homeostasis. Based on intestinal fungus changes in IBD patients, this article reviews the research progress in intestinal immunomodulation and therapeutic strategies derived from fungus-bacterial homeostasis.
