Research Progress on the Mechanism of Intestinal Administration of Chinese Medicine in Treating Ulcerative Colitis
10.14148/j.issn.1672-0482.2025.1300
- VernacularTitle:中药肠道给药治疗溃疡性结肠炎作用机制的研究进展
- Author:
Geng YU
1
;
Xu WANG
;
Lin DING
;
Tingting LIU
;
Yongqi ZHAO
;
Xia WU
;
Faming ZHANG
;
Xiuhong WU
Author Information
1. 黑龙江中医药大学药学院,黑龙江 哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
ulcerative colitis;
Chinese medicine;
intestinal administration;
mechanism of action;
intestinal barrier;
immunity;
in-testinal microbes
- From:
Journal of Nanjing University of Traditional Chinese Medicine
2025;41(10):1300-1311
- CountryChina
- Language:Chinese
-
Abstract:
Chinese medicine intestinal administration(CMIA)can avoid the degradation of drugs in gastric acid,bypass the first-pass effect of the liver,and deliver drugs directly to the lesion site.This approach increases local drug concentration,reduces drug dosage,and enhances bioavailability.This study systematically introduces the advantages,drug dosage forms,and whole-colon deliv-ery technologies of CMIA for treating UC,and reviews its mechanisms of action,including repairing intestinal epithelial layer and mu-cous layer,regulating the intestinal microbiota,improving immune function,and promoting local blood circulation.It also analyzes the current progress and limitations of research,aiming to provide a more solid theoretical basis for the treatment of UC with Chinese medi-cine and to offer references for the development of UC therapeutic drugs and administration methods.
