Clinical characteristics of 315 Han and Uyghur ulcerative colitis patients in a single center in Xinjiang Uygur Autonomous Region
10.3760/cma.j.cn101480-20230823-00012
- VernacularTitle:新疆地区单中心315例汉族和维吾尔族溃疡性结肠炎临床特点分析
- Author:
Weidong LIU
1
;
Qi JIANG
;
Wenjia HUI
;
Shenglong XUE
;
Huan LIU
;
Xiaoling HUANG
;
Feng GAO
Author Information
1. 新疆大学生命科学与技术学院，乌鲁木齐 830000
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Nationality;
Laboratory indicators;
Extraintestinal manifestations;
Helicobacter pylori
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(4):287-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinical characteristics of ulcerative colitis (UC) in Han and Uyghur patients in Xinjiang Uygur Autonomous Region.Method:Data of UC patients hospitalized at the People′s Hospital of Xinjiang Uygur Autonomous Region from January 2015 to June 2023 were retrospectively collected, with a focus on the differences in basic information, extraintestinal manifestations and biochemical laboratory indicators between Han and Uyghur patients.Results:A total of 315 UC patients were included, with 172 Han cases (54.6%) and 143 Uyghur cases (45.4%) . Compared to the Han group, the Uyghur group had a higher proportion of females, a lower average age, and lower rates of smoking and alcohol consumption (all P<0.05) . The Uyghur group showed a higher prevalence of hepatobiliary diseases and joint injuries as extraintestinal manifestations, although the differences were not statistically significant ( P all>0.05) . The Han group had a statistically significant higher level of intraepithelial neoplasia (χ 2 = 5.075, P<0.05) . The Uyghur group exhibited significantly higher levels of white blood cell count, platelet count, neutrophils, lymphocyte count, globulin, C-reactive protein, erythrocyte sedimentation rate, highly sensitive C-reactive protein, anti-neutrophil cytoplasmic antibodies, and H.pylori antibodies compared to the Han group (all P<0.05) . Both Han and Uyghur UC patients achieved satisfactory clinical efficacy. Conclusion:Uyghur UC patients have distinct characteristics, including a younger age of onset and more severe disease course, yet appropriate treatment can lead to satisfactory clinical outcomes.
