Abnormal functional connectivity network of posterior cingulate gyrus in first-episode adolescent schizophrenia: a fMRI study
10.3760/cma.j.issn.1006-7884.2019.02.004
- VernacularTitle:首次发病青少年精神分裂症患者的后扣带回功能连接网络异常
- Author:
Na OU
1
;
Ruofei JI
;
Xinsen WANG
;
Lihua ZHUO
;
Xiaoqi HUANG
;
Guoping HUANG
Author Information
1. 四川省精神卫生中心,绵阳621000;川北医学院,南充637000
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Adolescent;
Magnetic resonance imaging;
Resting state;
Posterior cingulate gyrus
- From:
Chinese Journal of Psychiatry
2019;52(2):123-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the potential neural mechanism of adolescent schizophrenia by analysis of the resting state functional connectivity(rs-FC) network of posterior cingulate gyrus(PCC) with functional magnetic resonance imaging (fMRI).Methods Twenty-one first-episode medication-naive adolescent patients with schizophrenia were recruited from outpatients and inpatients in the Sichuan Mental Health Center from December 2016 to January 2018,and 21 gender-,age-and education-matched healthy ones were as control.The illness severity was estimated by PANSS and Psychotic Symptom Rating Scales (PSYRAT).All subjects was scanned by resting-state brain fMRI.The PCC was defined as a seed region of interest(ROI) after the imaging preprocessing,and the functional connectivity between seed region and other brain regions were calculated after the imaging data preprocessing.Statistical analysis of image data was processed by REST software.Results Data of 19 patients and 21 healthy volunteers were included in statistical analysis after realignment.Compared to the control group,the patients group exhibited increased PCC rs-FC (P＜0.05,AlphaSim-corrected for multiple comparisons,cluster size＞40) in two brain regions including the left orbital part of inferior frontal gyrus extended to the left superior temporal gyrus (MNI:x=-45,y=27,z=-15;t=5.164) and the bilateral middle cingulate gyrus (MNI:x=-6,y=-15,z=30;t=4.789),and the weaker PCC rs-FC (P＜0.05,AlphaSim-corrected for multiple comparisons,cluster size＞40) with the left postcentral gyrus(MNI:x=60,y=-12,z=45;t=-3.585) and the fight postcentral gyrus (MNI:x=-24,y=-33,z=66;t=-4.932).The rs-FC between the left orbital part of inferior frontal gyrus and the PCC was positively correlated with the PANSS negative symptom scores (r=0.487,P=-0.034).Conclusion It showed altered rs-FC of the PCC related network in first-episode adolescent schizophrenia patients.The increased rs-FC between the PCC and the orbitofrontal cortex may be associated with negative symptoms in adolescent schizophrenia patients.
