Correlation between serum creatinine-to-cystatin C ratio and muscle mass and strength in peritoneal dialysis patients
10.3760/cma.j.cn441217-20241008-01011
- VernacularTitle:血肌酐/胱抑素C比值与腹膜透析患者肌肉量和肌力的相关性
- Author:
Nan ZHANG
1
;
Xinqiu LI
1
;
Xiao XU
1
;
Jie DONG
1
Author Information
1. 北京大学第一医院肾内科 北京大学肾脏疾病研究所 国家卫生健康委员会肾脏疾病重点实验室 教育部慢性肾脏病防治教育部重点实验室 中国医学科学院免疫介导肾病诊治创新单元，北京 100034
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Muscle strength;
Death;
Lean body mass;
Serum creatinine-to-cystatin C ratio;
Grip strength
- From:
Chinese Journal of Nephrology
2025;41(5):325-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlation between serum creatinine/cystatin C ratio (Scr/CysC) and muscle mass and muscle strength, and evaluate the predictive value of Scr/CysC for all-cause mortality in peritoneal dialysis patients.Methods:It was a prospective cohort study. The patients who received regular peritoneal dialysis treatment for more than 3 months and had stable conditions in the Renal Division of Peking University First Hospital from April 1, 2011 to August 1, 2012 were included, and the clinical data were collected. The patients were divided into the male group and the female group, and the differences of clinical data between the two groups were compared. The lean body mass (LBM) directly measured by the dual-energy X-ray absorptiometry (LBM-DEXA) was used as the reference gold standard and compared with the LBM estimated by the creatinine method (LBM-CK) and the anthropometric method (LBM-A). Muscle strength was measured by a grip strength meter for the dominant hand grip strength. Pearson correlation and multiple linear regression analysis method were used to analyze the correlations between Scr/CysC and LBM as well as grip strength, and subgroup analyses were conducted according to gender groups. Cox regression model was used to analyze the value of Scr/CysC in predicting all-cause mortality in peritoneal dialysis patients.Results:A total of 213 peritoneal dialysis patients were included in this study, including 95 males (44.6%) and 118 females (55.4%). The age was (56.46±12.42) years old. The dialysis age was 24.0 (9.0, 52.5) months. The baseline Scr/CysC was (1.77±0.73). LBM-DEXA ( t=-17.764, P<0.001), LBM-CK ( t=-7.702, P<0.001), LBM-A ( t=-16.813, P<0.001), grip strength ( t=-11.083, P<0.001) and Scr/CysC ( t=-2.965, P=0.003) in the male group were all significantly higher than those in the female group. Pearson correlation analysis showed that Scr/CysC was positively correlated with LBM-DEXA ( r=0.204, P=0.003), LBM-CK ( r=0.279, P<0.001), LBM-A ( r=0.198, P=0.004), and grip strength ( r=0.341, P<0.001). Multiple linear regression analysis showed that Scr/CysC wasn't independently correlated with LBM-DEXA, but was independently correlated with grip strength ( β=0.134, P=0.006). Cox regression analysis showed that baseline Scr/CysC was not an independent influencing factor of all-cause mortality in peritoneal dialysis patients ( HR=1.005, 95% CI 0.751-1.346, P=0.972). Conclusion:Scr/CysC is associated with muscle mass and muscle strength in peritoneal dialysis patients, but has no value in predicting all-cause mortality in peritoneal dialysis patients.
