Analysis of inflammatory indicators of fistulas tissue and blood in Crohn′s disease patients with perianal fistula
10.3760/cma.j.cn101480-20230725-00004
- VernacularTitle:克罗恩病肛瘘患者瘘管组织和血液的炎症指标分析
- Author:
Li ZHANG
1
;
Xueliang SUN
;
Juan HAN
;
Zhaozheng ZHANG
;
Ke WEN
Author Information
1. 安徽中医药大学研究生院，合肥 230012
- Publication Type:Journal Article
- Keywords:
Crohn′s disease;
Perianal fistula;
Fistula tissue;
Inflammatory indicators;
Difference;
Correlation
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(3):200-204
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the levels of inflammatory indicators of fistula tissue and blood of Crohn′s disease (CD) patients with perianal fistula and the clinical significance.Methods:A cross-sectional study was conducted. Clinical data of 60 CD patients with perianal fistula (CD fistula group) admitted to the Department of Anorectum, Suzhou Hospital of Traditional Chinese Medicine from May 2022 to May 2023 were collected, and 50 non-CD patients with perianal fistula were selected as non-CD fistula group. The level differences of tumor necrosis factor-α (TNF-α) , interleukin (IL) -12, IL-23, IL-17A, and IL-6 in fistula tissue, and the level differences of white blood cell (WBC) , C-reactive protein (CRP) , erythrocyte sedimentation rate (ESR) , platelet (PLT) , and fecal calprotectin (FC) were compared between the two groups. Pearson or Spearman rank correlation analysis was used to analyze the correlation of various indicators between fistula tissue and blood in CD fistula group.Results:In CD fistula group, there were 47 males and 13 females, with a mean age of (28.9 ± 8.5) years. In non-CD fistula group, there were 40 males and 10 females, with a mean age of (31.3 ± 5.9) years. There were no significant differences in age, gender, Park′s classification, perianal disease activity index and Wexner score between the two groups (all P>0.05) . Compared with the non-CD fistula group, the levels of TNF-α, IL-12, IL-23, IL-17A and IL-6 in fistula tissue were higher in CD fistula group, and the levels of CRP, PLT, FC and ESR were higher, with statistically significant differences (all P<0.05) . IL-12 was positively correlated with CRP ( r = 0.451, P<0.05) and WBC ( r = 0.414, P<0.05) in CD fistula group. Conclusion:Fistula inflammatory factors levels in CD patients with perianal fistula are higher than patients with non-CD fistula, and positively correlate with the levels of blood inflammatory indicators, which may serve as a reference for targeted precision treatment of perianal fistula CD.
