Effect of hyperbaric oxygen in the treatment of radiation encephalopathy: a systematic review of randomized controlled trials
10.3760/cma.j.issn.1009-6906.2018.04.006
- VernacularTitle:高压氧治疗放射性脑病随机对照试验的系统评价
- Author:
Xiaoling PENG
1
;
Xianrong ZENG
;
Fuqiong PAN
;
Qingming XIE
;
Huping CHEN
;
Mei PENG
Author Information
1. 四川省人民医院高压氧科, 成都,610072
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Radiation encephalopathy;
Meta-analysis;
Systematic review;
Randomized controlled trial
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2018;25(4):235-239
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess systematically the efficacy and safety of hyperbaric oxygen (HBO)combined with drugs in treatment of radiation encephalopathy (PREP).Methods Computer-aided information retrieval was made by using such databases as Pubmed,Cochrane Library,Embase,CBM,CNKI,VIP and WanFang data,at the same time,manual data retrieval was also made by searching related literature both at home and abroad.The time span for information retrieval was from the inception of the above-mentioned database to March 2018.After 2 reviewers independently screened the retrieved literature in accordance with the included and excluded criteria,and collected the retrieved papers and evaluated the methodological quality of the retrieved literature,meta-analysis was performed by using RevMan 5.2 software.Results Finally,a total of 16 randomized controlled trials (RCTs) involving 990 patients were included in the study.Meta analysis showed that effective rate and cure rate of the HBO combined with drugs group were respectively [OR =5.78,95％ CI (4.15,8.06)] (P＜0.01) and [OR=4.56,95c％CI (2.88,7.20)] (P＜0.01),which were superior to those of the simple drug treatment group.And the number of foci was less than that of the simple drug treatment group [OR =-2.63,95％ CI (-3.70,-1.56)] (P ＜ 0.01).Conclusion Current evidence shows that HBO combined with drug treatment could produce good effects on radiation encephalopathy.For this reason,it is worth further clinical popularization.
