Research progress on the mechanism of hypoxia-inducible factor-1α in inflammatory bowel disease
10.3760/cma.j.cn101480-20231030-00050
- VernacularTitle:缺氧诱导因子-1α在炎症性肠病中的作用机制研究进展
- Author:
Leilei CHEN
1
;
Dehuai JING
;
Yaowen ZHANG
;
Yan WANG
;
Wei YU
;
Zongjing HU
;
Fengqin ZHU
;
Guangxi ZHOU
Author Information
1. 山东大学齐鲁医学院，济南 250012
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Hypoxia-inducible factor-1α;
Intestinal epithelial barrier;
Inflammatory reaction
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(2):174-180
- CountryChina
- Language:Chinese
-
Abstract:
The development of inflammatory bowel diseases (IBD) is associated with genetics, environment, immune abnormalities, and intestinal flora, including ulcerative colitis (UC) and Crohn′s disease (CD). Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that promotes the expression of multiple genes in response to the hypoxic environment, and its roles in regulating intestinal barrier function, intestinal metabolism, and inflammatory and immune responses are research hotspots. This article reviews the role of HIF-1α in IBD by analyzing the relationships between HIF-1α and intestinal epithelial barrier and inflammatory response to provide new ideas for the clinical treatment of IBD.
