Diagnosis and treatment strategies of acute renal injury in pregnancy

VernacularTitle:妊娠期急性肾损伤诊治策略
Author: Nan ZHU ¹ ; Leiming CAI ; Weijie YUAN ; Yunfei CHEN
Author Information

1. 上海交通大学医学院附属第一人民医院肾内科，上海　200080
Publication Type:Journal Article
Keywords: Pregnancy period; Acute kidney injury; Diagnosis; Treatment
From: Chinese Journal of Nephrology 2024;40(12):972-977
CountryChina
Language:Chinese
Abstract: Acute kidney injury during pregnancy (P-AKI) threatens the health of both the mother and fetus, which should be given sufficient attention. During pregnancy, the kidneys undergo a series of physiological changes to adapt to the demands from the mother and infant, leading to the kidneys more susceptible to damage than non pregnant individuals. This article analyzes the pathophysiological changes, causes, diagnostic criteria, related diseases, and therapeutic measures of P-AKI. It also points out that for severe preeclampsia, thrombocytopenia syndrome, and acute fatty liver disease, the pregnancy should be terminated upon diagnosis. While for thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, plasma exchange should be the main treatment. Further analysis of the dialysis indications for P-AKI is aimed at providing reference for accurate clinical diagnosis and effective treatment, thereby improving the survival rates of pregnant women and fetuses.