Research progress in mouse model of atherosclerosis
10.3969/j.issn.1006-7795.2025.05.024
- VernacularTitle:动脉粥样硬化小鼠模型研究进展
- Author:
Wei MA
1
;
Huimin JIANG
;
Yifan ZHOU
;
Weiyue ZHANG
;
Hui LI
;
Chen ZHOU
;
Xunming JI
Author Information
1. 首都医科大学脑重大疾病研究中心,北京 100069
- Publication Type:Journal Article
- Keywords:
cardiovascular disease;
atherosclerosis;
animal models;
apolipoprotein E(ApoE);
low density lipoproteins receptor(LDLr);
plaque
- From:
Journal of Capital Medical University
2025;46(5):924-933
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular disease is the leading cause of death worldwide,with atherosclerosis(AS)-its core pathological manifestation-representing a multifactorial-driven chronic inflammatory disorder.The pathogenesis of AS involves intricate pathological mechanisms including dyslipidemia,inflammatory cascades,and plaque vulnerability,whose complexity necessitates animal models capable of accurately recapitulating specific pathological features.Genetically engineered murine models have emerged as pivotal tools for deciphering AS mechanisms,owing to their genetic manipulability,phenotypic traceability,and molecular conservation with human pathophysiology.This review provides a systematic overview of current methodologies for establishing AS mouse models,with particular emphasis on evaluating the pathological fidelity of dietary induction approaches,genetic modification strategies[notably apolipoprotein E(ApoE)-/-and low density lipoproteins receptor(LDLr)-/-models],and physical injury paradigms.
