Comparative efficacy of a miniature,implantable pelvic floor neuromuscular stimulation system at different frequencies for the treatment of stress urinary incontinence based on a rat model
10.3969/j.issn.1006-7795.2025.05.012
- VernacularTitle:微型植入式盆底神经肌肉电刺激系统在不同频率下治疗大鼠压力性尿失禁的疗效对比
- Author:
Bohong LONG
1
;
Chen LI
;
Han DENG
;
Haoyu SUN
;
Limin LIAO
;
Xing LI
Author Information
1. 温州医科大学附属第二医院育英儿童医院康复科,浙江 温州 325035;首都医科大学康复医学院中国康复研究中心泌尿外科,北京 100068
- Publication Type:Journal Article
- Keywords:
stress urinary incontinence;
pelvic floor electrical stimulation;
frequency;
neuromuscular stimulation;
implantable;
Wire-less
- From:
Journal of Capital Medical University
2025;46(5):839-844
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the comparative efficacy of different frequencies of pelvic floor electrical stimulation(PFES)on stress urinary incontinence(SUI)in rats.Methods Twenty female Sprague-Dawley rats were randomly divided into 6,15,30 and 50 Hz group by random number table method.All rats underwent vaginal dilatation(VD)to simulate postpartum SUI.One week after VD,the sneeze test was conducted to determine whether the modeling was successful.If the sneeze test was positive,the modeling was successful.The miniature and wireless electric pelvic floor stimulator were implanted into the pelvic floor muscle of the modeled rats,and PFES were treated for 2 weeks in each group at the rates of 6,15,30 and 50 Hz,respectively.The Leak point pressure(LPP)of all rats before VD,1 week after VD and 2 weeks after stimulation were measured by cystometrograms(CMGs)for comparison.Results LPP was significantly reduced in all groups of rats after VD 1 week(P<0.001).Compared with after VD 1 week,after two consecutive weeks of PFES at four different frequencies of 6,15,30 and 50 Hz,LPP was again significantly increased(P<0.001)and reached the baseline level(P>0.05)in all groups of rats.In the between-group comparison of the rats in each group,there was no significant difference in their LPP at baseline value,after VD 1 week and after stimulation 2 weeks(P>0.05).Conclusion The present study suggests that of the several stimulation frequencies explored so far,6 Hz may be a more appropriate choice for PFES.Further studies are still needed to evaluate more frequencies and the long-term efficacy of PFES.
