A diffusion tensor imaging study of brain white matter and cognitive function in first-episode of childhood and adolescence-onset schizophrenia
10.3760/cma.j.issn.1006-7884.2017.06.008
- VernacularTitle:首次发病儿童青少年精神分裂症患者脑白质弥散张量成像特点与认知功能的研究
- Author:
Yanhong XIA
1
;
Suqin GUO
;
Keyang PEI
;
Rongrong SHAO
;
Yinghui LIANG
;
Dan LUY
;
Haisan ZHANG
;
Yali LI
Author Information
1. 新乡医学院第二附属医院河南省精神病医院儿童少年精神科
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Child;
Adolescent;
Diffusion tensor imaging;
Cognition;
White matter
- From:
Chinese Journal of Psychiatry
2017;50(6):432-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the microstructural changes of brain white matter in first-episode of childhood and adolescence-onset schizophrenia and the relationship between the fractional anisostrapy (FA)values and cognitive function in patients.Methods This study was a case-control study,40 childhood and adolescence-onset schizophrenia patients aged 10-16 years 35 healthy children with sex,age,education and race matched to controls were chosen. All the subjects were conducted diffusion tensor imaging (DTI) scans, then using tract-based spatial statistics (TBSS) method to compare FA values of white matter fiber. The cognitive function was assessed with the (MATRICS Consensus Cognitive Battery,MCCB). The relationship between the FA values of different white matter and the cognitive function in the two group was analysed by using Pearson correlation analysis. Results Compared with the controls(n=34), FA values of patients(n=35) in the body of corpus callosum, genu of corpus callosum, splenium of corpus callosum, cingulum bundle, right upper corona radiate, upper left corona radiate significantly decreased (t=4.726, 2.855,2.547,2.943,3.178,2.969,all P<0.05).The FA values of the body of corpus callosum were positively correlated with the symbol coding, color, color words(r=0.34, 0.38, 0.36, all P<0.05) in patients. The FA value of the cingulum bundle were positively correlated with the Hapkins Verbal Learning Test-Revised (HVLT-R),the FA value of the upper left corona radiate were positively correlated with the Word fluency(r=0.34,0.37,both P<0.05).In the controls FA value of white matter in the body and genu of corpus callosum were positively correlated with the HVLT-R(r=0.34,0.51,both P<0.05).Conclusions The childhood and adolescence-onset schizophrenia showed microstructural changes in the brain regional white matter, the pathophysiological mechanism of cognitive impairment may be related to the abnormalities of the brain white matter microstructural structure.
