Aberrant subcortical structural covariant connectivity in patients with adolescent-onset schizophrenia
10.3760/cma.j.issn.1006-7884.2017.06.009
- VernacularTitle:早发青少年精神分裂症患者皮质下脑结构协变连接异常的研究
- Author:
Junjie ZHENG
1
;
Yan ZHANG
;
Jingping ZHAO
;
Huafu CHEN
Author Information
1. 成都,电子科技大学生命科学与技术学院神经信息教育部重点实验室
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Adolescent;
Subcortical structural;
Covariant connectivity
- From:
Chinese Journal of Psychiatry
2017;50(6):439-444
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether subcortical regions volumes show aberrant structural covariant connectivity in patients with adolescent-onset schizophrenia (AOS). Methods Thirty-nine first-episode drug-na(i)ve patients with AOS from 12 to 18 years old, and 31 age- and education- matched healthy controls were recruited and scanned with 3.0 T MRI station. Freesurfer software was used to preprocess the imaging data and to extract subcortical regions volumes.Linear correlation model was used to construct covariant connectivity.Then Z test was used to evaluate covariant connectivity differences between patients and controls. Results Compared with control group(n=29), patients(n=35) with AOS showed the reduced volume in left thalamus (7 755 mm3vs. 7 955 mm3,t=-2.16, P<0.05 uncorrected) and in left hippocampus (4 200 mm3vs. 4 331 mm3,t=-2.01, P<0.05 uncorrected); Patients also showed decreased covariant connectivity between left palladium and left putamen, between left hippocampus and left amygdala,between right amygdala and right thalamus,between right amygdala and right putamen,between left putamen and right thalamus (Z=1.88-2.87,P<0.05 FDR corrected). Conclusions The volume and covariant connectivity in parts of subcortical regions may be decreased in first-episode drug-na?ve patients with AOS. These abnormalities may provide subcortical limbic and basal ganglia regions structural maturation deficits in AOS.
