Working memory assessed by functional near-infrared spectroscopy in child patients with attention deficit hyperactivity disorder
10.3760/cma.j.issn.1006-7884.2017.06.011
- VernacularTitle:注意缺陷多动障碍患儿工作记忆功能的近红外光谱成像研究
- Author:
Shuo MIAO
1
;
Xin WANG
;
Yue GU
;
Junxia HAN
;
Wenhong SONG
;
Zhao LIU
;
Fengmin ZHOU
;
Xiaoli LI
;
Jian YANG
Author Information
1. 首都儿科研究所附属儿童医院神经内科
- Publication Type:Journal Article
- Keywords:
Attention deficit disorder with hyperactivity;
Spectroscopy;
near-infrared;
Child;
Working memory
- From:
Chinese Journal of Psychiatry
2017;50(6):453-457
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the activation characteristics in the prefrontal cortex(PFC) of children with attention deficit hyperactivity disorder (ADHD) in the working memory tasks by using functional near-infrared spectroscopy(fNIRS). Methods In this study, 12 children with ADHD and 13 typically developing children were studied. N-back task was chosen as the neuropsychology task. The functional blood oxygen metabolism signals and the correct number of key-press were recorded when the children performed n-back task by using fNIRS. The average change of the hemoglobin concentration and the correct number of keys were compared by t test.Results (1)In the behavior data,ADHD children had a lower correct number of key-press compared with typically developing children at both 0-back and 1-back task conditions(0-back:t=-2.222,P=0.043;1-back:t=-3.276,P=0.005).(2)For the 0-back task condition, there was no statistical difference between the two groups. For the 1-back task condition, task-related increment of the oxygen-Hb concentration, the marker of cortex activation, in ADHD children was significantly smaller than the typically developing children for channel 18, which was located in left dorsolateral prefrontal cortex(DLPFC)(ADHD children:(0.022±0.040)mmol/(L·mm);Typical Developing Children:(0.085 ± 0.040)mmol/(L·mm); t=3.88,P<0.05). Conclusions The PFC activation in ADHD children may be significantly decreased, which probably indicates a working memory defect in ADHD children.
