Crohn′s disease with NLRP12 genetic variation: report of 2 cases with literature review
10.3760/cma.j.cn101480-20230130-00009
- VernacularTitle:父子克罗恩病伴 NLRP12基因变异二例并文献复习
- Author:
Ruobing LIU
1
;
Xiangsu LI
;
Yang HUANG
;
Ailan LI
;
Fen WEN
;
Xue ZHAO
;
Chaonan WANG
;
Xueyi XIAO
;
Qingqing YANG
;
Xudong WU
Author Information
1. 徐州医科大学盐城临床学院 盐城市第一人民医院全科医学科，盐城 224006
- Publication Type:Journal Article
- Keywords:
Crohn′s disease;
Inflammatory bowel disease;
Gene, NLRP12;
NOD-like receptor family;
Gut microbiota;
Inflammatory cytokine
- From:
Chinese Journal of Inflammatory Bowel Diseases
2024;08(1):101-104
- CountryChina
- Language:Chinese
-
Abstract:
A pair of father-son Crohn′s disease (CD) patients with NOD-like receptors family pyrin domain containing 12 ( NLRP12) gene c.1382 mutation was reported. Through the relevant literature review, we summarize the other CD patients complicated with NLRP12 genetic variation at home and abroad and the mechanism of NLRP12 in inflammatory bowel disease. This study aims to provide reference for the subsequent exploration of individulized treatment.
