The role of lactylation modification in the pathogenesis of cardiovascular diseases
10.20039/j.cnki.1007-3949.2025.06.002
- VernacularTitle:乳酸化修饰在心血管疾病发病机制中的作用
- Author:
Mingxue ZHOU
1
Author Information
1. 首都医科大学附属北京中医医院;北京市中医药研究所心血管病研究室,北京市 100010
- Publication Type:Journal Article
- Keywords:
lactic acid;
lactylation modification;
histone lactylation;
cardiovascular diseases;
mechanism of action;
epigenetics
- From:
Chinese Journal of Arteriosclerosis
2025;33(6):469-473,480
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular diseases(CVD)are common complex diseases caused by the interaction of genetic and environmental factors and are closely related to epigenetic modifications.Recent studies have found that lactylation modi-fication,a newly discovered epigenetic mechanism,regulates histones by adding lactyl groups to lysine residues,thereby promoting the transcription and expression of specific genes.Moreover,it also affects the structure and function of non-histone proteins and plays important roles in the pathogenesis of CVD such as atherosclerosis(As),myocardial infarction(MI),ischemia reperfusion injury(IRI)and heart failure(HF)by regulating protein function and gene expression.In this review,the author summarizes and elaborates on the relevant literature on the roles of lactylation modification in CVD published in recent years,in order to provide reference for future research.
