Research progress on the correlation between Janus tyrosine protein kinase/signal transduction and transcription activating factor pathway and type 1 diabetes mellitus
10.3969/j.issn.1006-6187.2025.10.012
- VernacularTitle:Janus酪氨酸蛋白激酶/信号转导及转录激活因子通路与1型糖尿病相关性的研究进展
- Author:
Yunwen TAO
1
;
Heming GUO
1
;
Sicheng LI
1
;
Chen FANG
1
Author Information
1. 215004 苏州大学附属第二医院内分泌科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 1;
Janus tyrosine protein kinase/signal transduction and transcription activating factor pathway;
Correlation
- From:
Chinese Journal of Diabetes
2025;33(10):793-796
- CountryChina
- Language:Chinese
-
Abstract:
Type 1 diabetes mellitus(T1DM)is a specific autoimmune disease.In addition to traditional exogenous insulin supplementation therapy,immunomodulators and cell therapy methods have received attention.The Janus tyrosine protein kinase/signal transduction and transcription activating factor(JAK/STAT)pathway is widely present in cells,maymediate various cytokine signaling pathways and participate in islets β cell autoimmune destruction in T1DM.This article reviews the research progress on the correlation between the JAK/STAT pathway and T1DM.
