Correlation between changes in blood glucose and barrier dysfunction in patients with diabetes mellitus and ulcerative colitis
10.3969/j.issn.1006-6187.2025.10.007
- VernacularTitle:糖尿病合并溃疡性结肠炎患者血糖与屏障功能损伤相关性的研究
- Author:
Keyu WANG
1
;
Li ZHANG
1
;
Huili WU
1
Author Information
1. 450000 郑州大学附属郑州中心医院消化内科
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Ulcerative colitis;
Glycemic control;
Barrier dysfunction
- From:
Chinese Journal of Diabetes
2025;33(10):755-759
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between blood glucose(BG)control and barrier dysfunction in diabetes mellitus(DM)patients with ulcerative colitis(UC).Methods A total of 120 patients with DM and UC admitted to the Department of Gastroenterology of our hospital between January 2021 and January 2024 were selected and divided into injury group(n=68)and non-injury group(n=52)according to the injury of intestinal barrier function.Pearson correlation analysis was used to analyze the correlation between hemoglobin A1c(HbA1c),fasting plasma glucose(FPG),2 hPG and D-lactic acid(D-LA),diamine oxidase(DAO),lipopolysaccharide(LPS),and Galectin-3.Logistic regression analysis was used to analyze the influencing factors for intestinal barrier dysfunction.Receiver operator characteristic(ROC)curve was drawn to analyze the diagnostic value of BG level for intestinal barrier dysfunction.Results The levels of HbA1c,FPG,2 hPG,D-LA,DAO,and LPS were higher in the injury group than in the non-injury group(P<0.05),and the level of Galectin-3 was lower in the injury group than in the non-injury group(P<0.05).Pearson correlation analysis showed that HbA1c,FPG,and 2 hPG levels were positively correlated with D-LA,DAO,and LPS(P<0.05),and negatively correlated with Galectin-3(P<0.05).Logistic regression analysis showed that HbA1c,FPG and 2 hPG were the influencing factors for intestinal barrier dysfunction.ROC curve analysis showed that the area under the curve of HbA1c,FPG and 2 hPG was 0.968,0.942 and 0.910 for predicting intestinal barrier dysfunction.Conclusions BG level affects the damage of intestinal barrier function,and the risk of intestinal barrier function damage can be reduced by strengthening BG control in clinical practice.
