The influence of exclusive enteral nutrition on plasma amino acid levels in patients with Crohn′s disease
10.3760/cma.j.cn101480-20230505-00073
- VernacularTitle:全肠内营养治疗对克罗恩病患者血浆氨基酸水平的影响
- Author:
Bingyang LI
1
;
Na DIAO
;
Xinyu LIU
;
Minzhi LIN
;
Kang CHAO
;
Xiang GAO
Author Information
1. 中山大学附属第六医院消化内科，广州 510655
- Publication Type:Journal Article
- Keywords:
Crohn′s disease;
Exclusive enteral nutrition;
Amino acid;
Clinical remission.
- From:
Chinese Journal of Inflammatory Bowel Diseases
2023;07(3):255-260
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of exclusive enteral nutrition (EEN) on plasma amino acid levels in patients with Crohn′s disease (CD) .Methods:Adult patients with moderate to severe active CD in the Sixth Affiliated Hospital of Sun Yat-sen University from December 1, 2020 to December 31, 2021 were prospectively recruited. All the participants received nasogastric EEN monotherapy for 8 weeks. Patients were divided into clinical response group and non-response group according to CD activity index (CDAI). Clinical data were collected from all the participants before and after EEN. Targeted metabolomics was used to detect and analyze the changes of 25 amino acids levels in plasma in CD patients before and after EEN, as well as the differences between response group and non-response group.Results:Thirteen patients were included in the study. The clinical remission rate reached 69.2% (9/13) after 8 weeks of EEN treatment. Compared with pre-treatment, the plasma levels of tryptophan, threonine, alanine, proline and cysteine in CD patients were significantly higher after EEN treatment. At week 8 after EEN, tryptophan metabolites including indole acetic acid and indole acetamide were significantly lower in patients with clinical remission compared to patients without remission. Correlation analysis showed the plasma levels of tryptophan was negatively correlated with CDAI and erythrocyte sedimentation rate (ESR), and the level of kynurenine was negatively correlated with ESR.Conclusion:EEN therapy is an effective way to induce clinical remission in active CD patients. After EEN, plasma levels of tryptophan, threonine, alanine, proline and cysteine are significantly increased. Tryptophan and cysteine metabolisms may be the key pathways leading to the efficacy of EEN treatment.
