Meta-analysis of pathogen distribution and drug resistance trends in elderly patients with stroke-associated pneumonia in China
10.16753/j.cnki.1008-2344.2025.04.007
- VernacularTitle:我国老年脑卒中患者肺部感染的病原菌分布及耐药性变迁的荟萃分析
- Author:
Bin CUI
1
;
Zhiyuan TIAN
;
Chennian XU
;
Rui QIAO
Author Information
1. 陆军第七十九集团军医院门诊部,辽宁 辽阳 111000
- Publication Type:Journal Article
- Keywords:
elderly;
stroke;
pneumonia;
drug resistance
- From:
Journal of Shenyang Medical College
2025;27(4):375-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the trends of pathogen distribution and drug resistance in elderly patients with stroke-associated pneumonia(SAP)in China,providing references for clinical antibiotic selection and application.Methods:A meta-analysis was conducted to comprehensively evaluate changes in resistance rates of major pathogens isolated from elderly SAP patients to key clinical antibiotics over the past 10 years.The trends of antimicrobial resistance were analyzed.Results:A total of 12 qualified articles were screened out,involving 1 202 cases of pulmonary infections and 1 315 pathogenic isolates.Gram-negative bacilli accounted for 951 strains(72.32%),Gram-positive cocci for 278 strains(21.14%),and fungi for 86 strains(6.54%).The top five pathogens were Klebsiella pneumoniae,Pseudomonas aeruginosa,Acinetobacter Baumannii,Staphylococcus aureus and Escherichia coli.The resistance rates to various antibiotics showed minor fluctuations across years.Conclusions:Gram-negative bacilli dominate pulmonary infections in elderly stroke patients,with a high proportion of multidrug-resistant strains.Strengthened pathogen surveillance and rational antibiotic use are critical in clinical practice.
