Preliminary Study on the Efficacy of Microwave Ablation in Treating Breast Cancer Involving the Skin or Nipple-Areola Complex
10.12290/xhyxzz.2024-1084
- VernacularTitle:微波消融治疗侵犯皮肤或乳头乳晕复合体乳腺癌的初步研究效果
- Author:
Xiaopeng GAO
1
;
Qidi HOU
;
Ran JI
;
Yuqing DAI
;
Xin LI
;
Ping LIANG
;
Jie YU
Author Information
1. 中国人民解放军总医院第五医学中心肿瘤医学部介入超声科,北京 100166
- Publication Type:Journal Article
- Keywords:
breast cancer;
microwave ablation;
nipple-areola complex;
aesthetic satisfaction;
quality of life
- From:
Medical Journal of Peking Union Medical College Hospital
2025;16(4):892-898
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily investigate the safety and efficacy of percutaneous microwave ab-lation(MWA)in patients with advanced breast cancer involving the skin or nipple-areola complex(NAC).Methods This study included breast cancer patients with skin or NAC involvement treated at the Fifth Medical Center of the Chinese PLA General Hospital from January 2011 to August 2024.Patients underwent percutaneous MWA with water isolation technique to protect surrounding tissues.Clinical data were retrospectively collected,and the technical success rate,complications,prognosis,patient satisfaction with breast aesthetics,and quality of life improvement were analyzed.Results A total of 19 patients(24 lesions)meeting the inclusion and ex-clusion criteria were analyzed.The cases included 4 with T4N0M0,2 with T4N1M0,3 with T4N2M0,1 with T4N3M0,1 with T4N2M1,and 8 with T4N3M1.The average diameter of the 24 lesions was(4.9±3.4)cm,with an average of(1.6±0.6)ablation sessions per lesion.The median ablation time was 36.9(26.1,61.7)minutes,and the median ablation energy was 84.2(45.6,149.2)kJ.The technical success rate was 100%.Postoperatively,7 patients(7/19,36.8%)experienced skin burns around the lesion or nipple shedding,all of which healed naturally.The median overall survival was 35.0(17.0,45.5)months,and the median recur-rence-free survival was 17.0(11.0,38.5)months.Patient satisfaction with post-treatment breast aesthetics was 89.5%,and all patients reported significant improvement in their quality of life.Conclusions Percutane-ous microwave ablation for breast cancer involving the skin or NAC was preliminary demonstrates to be safe and effective,suggesting its potential as a viable treatment option for patients with inoperable breast cancer.
