Research progress of hydrogen sulfide in ferroptosis-mediated neurodegenerative diseases
10.11659/jjssx.11E024124
- VernacularTitle:硫化氢在铁死亡介导的神经退行性疾病中的研究进展
- Author:
Lin-cen XIAO
1
;
Yu-si-han ZENG
;
Jia HONG
;
Ke-ting LIU
;
Li XIAO
Author Information
1. 成都医学院,四川 成都 610500
- Publication Type:Journal Article
- Keywords:
hydrogen sulfide;
ferroptosis;
neurodegenerative diseases
- From:
Journal of Regional Anatomy and Operative Surgery
2025;34(10):923-928
- CountryChina
- Language:Chinese
-
Abstract:
Ferroptosis is a programmed cell death depends on iron and lipid peroxidation,which has been recognized as the key pathogenic factor for the occurrence of various diseases in recent years,especially playing a significant role in neurodegenerative diseases.Ferroptosis triggers lipid peroxidation and oxidative stress in neuronal cells,leading to neuronal damage and death,thereby accelerating disease progression.Hydrogen sulfide,as an endogenous gaseous signaling molecule,exhibits multiple protective effects,including anti-inflammatory,antioxidant,and anti-ferroptosis properties.Hydrogen sulfide can effectively inhibit the occurrence of ferroptosis through various mechanisms,such as regulating iron metabolism,inhibiting lipid peroxidation,and enhancing the activity of antioxidant enzymes,thereby slowing down the progression of neurodegenerative diseases.This article reviews the related research progress on hydrogen sulfide and ferroptosis and ferroptosis-mediated neurodegenerative diseases,and analyzes the underlying mechanisms,aims to provide new insights and theoretical foundations for the treatment of neurodegenerative diseases.
