Research progress on the role and mechanism of high mobility group box protein 1 after spinal cord injury
- VernacularTitle:高迁移率族蛋白B1在脊髓损伤后的作用及机制研究进展
- Author:
Xin XUE
1
;
Chang-zheng YIN
;
Jin-hui CHEN
;
Lu-rong HUANG
;
Xin ZHENG
;
Yi-min LI
;
Guo-bao XIAO
;
Ping ZHANG
;
Jian-hua ZHAO
Author Information
- Publication Type:Journal Article
- Keywords: HMGB1; spinal cord injury; neuroinflammation; neural stem cell; neuroprotection
- From: Journal of Regional Anatomy and Operative Surgery 2025;34(10):918-923
- CountryChina
- Language:Chinese
- Abstract: High mobility group box protein 1(HMGB1)is one of the most widely expressed protein member in the HMGs family,which is well known for its involvement in the body inflammatory response.Previous researches have found that it plays a significant role in cell migration,immune identification and neuroprotection.Spinal cord injury is a disease that causes severe damage to the nervous system,and neural circuits are disrupted after a spinal cord injury,which leads to many conditions including ischemia and hypoxia,inflammatory responses,demyelinating lesions,and glial scar formation that are detrimental to nerve regeneration and repair,making it one of the most difficult diseases to treat in the modern spinal surgery field.HMGB1 is upregulated after spinal cord injury,thereby regulating neuroinflam-matory responses,and participating in the neuronal apoptosis,promoting neuronal regeneration,and inducing neural stem cell differentiation and migration,which plays an important role in the process of neural function recovery.This paper summarizes the structure and function of HMGB1,as well as its role in spinal cord injury,in order to provide direction for founding therapeutic target for neurological function recovery after spinal cord injury.
