Antitumor Effect of Resveratrol:Mechanism and Research Progress

VernacularTitle:白藜芦醇的多效抗肿瘤作用:机制及研究进展
Author: Xiaonan WEI ¹ ; Yiqiong YANG ; Yahui CAI ; Chaoqiang GUO ; Yanping LI
Author Information

1. 济宁医学院精准医学研究院山东省慢性非传染性疾病精准医学特色实验室,山东济宁 272067
Publication Type:Journal Article
Keywords: resveratrol; polyphenolic compounds; antitumor effects; tumor prevention; tumor therapy
From: Medical Journal of Peking Union Medical College Hospital 2025;16(4):964-972
CountryChina
Language:Chinese
Abstract: Resveratrol,a natural polyphenolic compound widely found in a variety of plants such as grapes,apples,blueberries,plums and peanuts,has been widely studied for its multiple biological functions such as its antioxidant,anti-inflammatory,antiviral,neuroprotective,cardioprotective,immunomodulatory and antitumor effects.This review aims to analyze the pleiotropic antitumor effects of resveratrol,including inhibition of tumor cell proliferation and metastasis,promotion of tumor cell autophagy,improvement of the tumor microenvironment,reduction of tumor cell resistance,and induction of epigenetic modifications.The re-search progress of resveratrol in colorectal,breast,lung,cervical,prostate,and oral cancers is also summa-rized.With its wide range of anti-tumor activities,resveratrol is expected to be a potential drug for tumor pre-vention and treatment.