Progress of the intestinal epithelial development pathways in inflammatory bowel disease
10.3760/cma.j.cn101480-20220826-00137
- VernacularTitle:肠上皮发育通路在炎症性肠病中的研究进展
- Author:
Kun ZHANG
1
;
Lingfen XU
1
Author Information
1. 中国医科大学附属盛京医院小儿消化内科，沈阳 110004
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Signal transduction;
Intestinal epithelial barrier;
Development
- From:
Chinese Journal of Inflammatory Bowel Diseases
2023;07(3):301-306
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a type of recurrent chronic non-specific inflammatory disease of the intestinal tract with unclear etiology. The pathological features of IBD patients are the dysfunction of intestinal epithelial barrier and destruction of crypt. More and more evidences show the importance of epithelial barrier integrity in intestinal homeostasis. Barrier dysfunction in IBD patients occurs earlier than clinical symptoms, and accelerates the progression of the disease. This article mainly reviews the relationship between intestinal epithelial barrier and IBD from the composition and development of intestinal epithelium, and the progress of developmental signaling pathways in the pathogenesis of IBD, in order to provide the new ideas for the treatment of IBD.
