Research Progress on the Role of the Interaction Between Chronic Inflammation and Fibrosis in Diabetic Nephropathy
10.12290/xhyxzz.2024-1078
- VernacularTitle:慢性炎症与纤维化相互作用在糖尿病肾病中作用的研究进展
- Author:
Jin XU
1
;
Jianxing LI
;
Zhenhua LIU
;
Xinli ZHANG
Author Information
1. 甘肃省中医院肾病科,兰州 730000
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
inflammatory response;
renal fibrosis;
epithelial-mesenchymal transition;
extracellular matrix;
signal pathway
- From:
Medical Journal of Peking Union Medical College Hospital
2025;16(4):980-988
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy(DN),a primary cause of end-stage renal disease(ESRD)in diabetic patients,is pathologically characterized by chronic inflammation and renal fibrosis.Chronic inflammation promotes renal cellular damage,epithelial-mesenchymal transition,and extracellular matrix(ECM)accumulation through mechanisms including immune cell activation,pro-inflammatory cytokine secretion,and initiation of multiple sig-naling pathways.Excessive ECM deposition disrupts renal architecture and drives tubulointerstitial expansion,thereby accelerating renal functional decline.Recent studies demonstrate that chronic inflammation and fibrosis synergistically propagate DN progression via bidirectional crosstalk.Inflammation serves as an early driver of fibro-genesis and further amplifies fibrotic processes through positive feedback mechanisms,establishing a self-perpetu-ating inflammation-fibrosis vicious cycle.However,the precise molecular interplay between chronic inflammation and fibrosis remains incompletely elucidated.Thus,in-depth exploration of their interaction mechanisms is crucial for developing novel DN interventions.This review delineates the pathogenic roles of chronic inflamma-tion and fibrosis in DN to advance mechanistic understanding and provide foundational insights for designing in-novative therapeutic strategies.
