Research progress of omics technologies in thyroid dysfunction
10.3969/j.issn.1006-5725.2025.20.020
- VernacularTitle:组学技术在甲状腺功能障碍中的研究进展
- Author:
Wenyan ZHANG
1
;
Feifei SHAO
;
Limin TIAN
Author Information
1. 甘肃中医药大学第一临床医学院(甘肃 兰州 730000)
- Publication Type:Journal Article
- Keywords:
thyroid dysfunction;
genomics;
transcriptomic;
proteomics;
metabolomics;
lipido-mics
- From:
The Journal of Practical Medicine
2025;41(20):3288-3296
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid dysfunction(TD)is a prevalent disorder of the endocrine system.Owing to its non-specific clinical symptoms and the limitations inherent in current diagnostic approaches,there is a pressing need to further investigate its underlying pathogenesis and identify novel biomarkers.As a pivotal component of systems biology,omics technologies offer a promising avenue for uncovering the molecular mechanisms of TD by integrating high-throughput data.This thesis presents a comprehensive review of recent advancements in genomics,transcriptomics,proteomics,metabolomics,lipidomics,and multi-omics research related to TD.It examines genetic variations and epigenetic regulatory mechanisms from multiple molecular levels,including DNA,RNA,proteins,and metabolites.Furthermore,it elucidates the metabolic disturbances associated with TD and the modes of action of relevant therapeutic agents,contributing to the development of potential biomarkers and drug targets for early detection and intervention.By synthesizing findings across various omics platforms,this thesis aims to delineate the complex network interactions underlying TD and to provide valuable insights and strategies for future clinical management,as well as personalized diagnosis and treatment.
