The role of mTOR signaling pathways in inflammatory bowel disease
10.3760/cma.j.cn101480-20220815-00126
- VernacularTitle:mTOR信号通路在炎症性肠病中的作用
- Author:
Qi ZHANG
1
;
Bingjie XIANG
;
Min ZHI
;
Min ZHANG
Author Information
1. 中山大学附属第六医院消化内科，广州 510655
- Publication Type:Journal Article
- Keywords:
Inflammatory bowel disease;
Mammalian target of rapamycin;
Signaling pathway;
Treatment
- From:
Chinese Journal of Inflammatory Bowel Diseases
2023;07(1):81-85
- CountryChina
- Language:Chinese
-
Abstract:
Inflammatory bowel disease (IBD) is a chronic non-specific intestinal inflammatory disease with unknown pathogenesis, and some IBD patients do not respond well to conventional medications. Currently, mammalian target of rapamycin (mTOR) can affect intestinal autophagy and inflammation progress through various mechanisms such as PI3K/AKT/mTOR, TLR4/MAPK/mTOR and AMPK/mTOR. By this way, mTOR can play a significant role in its pathogenesis. Targeting mTOR signaling pathway provides new therapeutic options for IBD. In this article, the mechanisms of mTOR signaling pathway in IBD and the targeted treatment of mTOR signaling pathway for IBD were summarized.
