Research progress on bidirectional regulation of animal cognitive behavior by microbial-gut-brain axis
10.16753/j.cnki.1008-2344.2025.05.015
- VernacularTitle:微生物-肠-脑轴双向调控动物认知行为的研究进展
- Author:
Yuqiang WANG
1
;
Xuxin LU
;
Cuie DENG
;
Yingxian MAO
;
Weiwei ZHANG
Author Information
1. 沈阳医学院护理学院,辽宁 沈阳 110034
- Publication Type:Journal Article
- Keywords:
microbiota-gut-brain axis;
neuroinflammation;
oxidative stress;
autophagy;
cognition behaviour
- From:
Journal of Shenyang Medical College
2025;27(5):527-534
- CountryChina
- Language:Chinese
-
Abstract:
Cognitive impairment is one of the manifestations of nervous system injury,which is mainly closely related to neurodegeneration,and the incidence rate is increasing year by year,which has seriously affected the health level of the population.The gut microbiota plays an important role in the health of the body and participates in the regulation of the cognitive behavior of body.The microbiome-gut-brain axis acts as a bridge connecting gut microbiota and the nervous system,and plays a regulatory role between gut microbiota and the nervous system.Therefore,this review summarizes the latest progress in the effects of gut microbiota and nervous system on the cognitive ability of body through the bidirectional regulation of neurotransmitters,gut microbiota derivatives,neuroinflammation,oxidative stress,autophagy and their crosstalk through the microbial-intestinal-brain axis,and providing a reference for the clinical research of targeted transplantation of gut microbiota for preventing and treating cognitive disorders.
