Psoriasis-atopic dermatitis overlap phenotype: immune dysregulation mechanisms and emerging clinical insights
- VernacularTitle:银屑病-特应性皮炎重叠表型：免疫失衡机制与临床诊治新视角
- Author:
Zhiqiang SONG
1
;
Yuanxiong HE
1
;
Anqi CHEN
1
Author Information
- Publication Type:Journal Article
- Keywords: Dermatitis, atopic; Psoriasis; Eczema; Overlap; Immune mechanism; Molecular targeted therapy
- From: Chinese Journal of Dermatology 2025;58(11):1009-1014
- CountryChina
- Language:Chinese
- Abstract: Atopic dermatitis and psoriasis are two chronic inflammatory skin diseases with distinct immune mechanisms, primarily driven by Th2-type inflammation and Th1/Th17 pathways, respectively. However, some patients may simultaneously or sequentially exhibit overlapping phenotypes of atopic dermatitis and psoriasis (psoriasis-atopic dermatitis overlap, PAO), characterized by the coexistence of scaly erythema and eczematous lesions. Currently, the nomenclature, diagnostic criteria, and pathogenesis of PAO remain unclear, and its incidence is increasing due to the widespread use of targeted therapies. The diagnosis of PAO requires an integrated assessment of clinical features, histopathological findings, and biomarker profiles, while treatment necessitates a balance between immune modulation and individualized strategies. This article summarizes the characteristic manifestations of and genetic-immune interactions involved in PAO based on clinical practice, and explores diagnostic challenges and therapeutic options to address this complex and increasingly prominent clinical issue.
