Progress in role of joint barrier dysfunction in joint diseases
10.3969/j.issn.1000-4718.2025.07.023
- VernacularTitle:关节屏障失衡在关节疾病中作用的研究进展
- Author:
Rui PENG
1
;
Xingsheng ZHA
;
Yachen PENG
;
Huantian ZHANG
Author Information
1. 暨南大学附属第一医院骨关节外科,暨南大学再生医学教育部重点实验室,广东 广州 510000
- Publication Type:Journal Article
- Keywords:
joint barrier;
osteoarthritis;
rheumatoid arthritis;
gouty arthritis;
immune homeostasis
- From:
Chinese Journal of Pathophysiology
2025;41(7):1442-1448
- CountryChina
- Language:Chinese
-
Abstract:
Joint diseases have traditionally been linked to cartilage degeneration and inflammation,often ne-glecting the vital role of the joint barrier.This review introduces the novel concept of the"joint barrier"as an essential ana-tomical and functional unit in maintaining joint homeostasis.We systematically elucidate its structural components and functional characteristics,underscoring how dysfunction of the joint barrier contributes to the pathogenesis of various joint diseases.This perspective provides fresh insights into disease mechanisms and potential therapeutic targets.We highlight cutting-edge findings on the molecular regulatory mechanisms underlying joint barrier imbalance,focusing on epigenetic modifications,metabolic reprogramming,and intercellular communication networks.These discoveries establish a new framework for understanding joint pathology and identifying innovative intervention strategies.Additionally,we propose forward-thinking research directions with significant translational potential,including exploring the association between im-mune components and synovial barrier function,developing novel drugs targeting the barrier microenvironment,and inves-tigating the regulatory mechanisms of joint barrier imbalance influenced by systemic factors.These strategies promise to revolutionize the diagnosis,treatment,and prevention of joint diseases.By integrating the latest research and proposing fu-ture directions,this review offers a comprehensive understanding of joint barrier disorders and their implications for joint diseases,paving the way for new therapeutic approaches and concepts in the field.
