Progress in neuroprotective effect of glycine in ischemic stroke
10.3969/j.issn.1000-4718.2025.07.022
- VernacularTitle:甘氨酸在缺血性脑卒中神经保护作用的研究进展
- Author:
Yinglu CAI
1
;
Zheng CHEN
;
Wenyang LI
;
Hua YAO
Author Information
1. 桂林医科大学广西脑与认知神经科学重点实验室,广西 桂林 541004
- Publication Type:Journal Article
- Keywords:
glycine;
ischemic stroke;
neuroprotection;
glycine receptors;
signaling pathways
- From:
Chinese Journal of Pathophysiology
2025;41(7):1435-1441
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke,which presents a heavy medical,social,and economic burden worldwide,is now the second-leading cause of high morbidity,disability,mortality,and recurrence.However,its mechanism remains un-covered.Glycine,serves as a dual-role neurotransmitter,is involved in several cellular processes.Recent studies have shown that glycine can protect against ischemic stroke by reducing cell death,attenuating glutamate excitotoxicity,inhibit-ing inflammatory responses,and inducing vascular remodeling.This review aims to provide a comprehensive overview of glycine's biological functions,receptor characteristics,signal transduction mechanisms,and highlight glycine's protec-tive role in ischemic stroke.
