Application of cell ablation in neurobiological and neurological system disease research
10.12007/j.issn.0258-4646.2025.07.013
- VernacularTitle:细胞消融在神经生物学和神经系统疾病研究中的应用
- Author:
Chong CHEN
1
;
Siyuan WANG
;
Xiaoqiao HE
;
Weidong ZHAO
Author Information
1. 中国医科大学第一临床学院,沈阳 110122
- Publication Type:Journal Article
- Keywords:
cell ablation;
nervous system;
diphtheria toxin;
caspase
- From:
Journal of China Medical University
2025;54(7):648-652,669
- CountryChina
- Language:Chinese
-
Abstract:
Cell ablation has recently emerged as a valuable technique for investigating cell lineage and function during the development of organisms.The nervous system contains diverse cellular populations,whose roles under physiological and pathological conditions are still not fully understood.Various cell ablation methods have been reported to specifically ablate different types of cell populations in the nervous system and have also been used to study cellular functions under physiological conditions as well as the pathogenesis of neurologi-cal system diseases.In this article,we have summarized common cell ablation techniques and focus on their applications in neurobio-logical and neurological system disease research.
