Effect of hyperbaric oxygen on the proliferation of lung mesenchymal cell in rabbits with experimental decompression sickness
10.3760/cma.j.issn.1009-6906.2008.05.008
- VernacularTitle:高压氧对实验性减压病兔肺间质细胞增生的影响
- Author:
Tao KUANG
1
;
Jun WANG
;
Yi-ping JIANG
;
Guang-kai GAO
;
Yong-liang SHI
;
Di WU
;
Ying YANG
Author Information
1. 青岛大学医学院附属医院,山东省青岛,266071
- Publication Type:Journal Article
- Keywords:
Decompression sickness;
Lung mesenchymal cell;
Proliferation;
Rabbit;
Hyperbaric oxygen
- From:
Chinese journal of nautical medicine and hyperbaric medicine
2008;15(5):283-285
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of hyperbaric oxygen (HBO) on the changes of the proliferation of lung mesenchymal cell in rabbits with experimental decompression sickness (DCS). Methods Thirty-eight rabbits were put into the hyperbaric chamber. The pressure was increased to O. 6 Mpa within 5 min using compressed air and maintained for 60 rain, and then was decompressed to normal pressure within 3-5 min. Rabbits in HBO-1 group were exposed to HBO one time 1 h after decompression; rabbits in HBO-4 group were exposed to HBO (0.25 Mpa) once a day 1 h to 3 d after decompression. DCS control group: rabbits were exposed to the normal air once a day for 4 days after decompression. Normoxic hyperbaric nitrogen (NOHN) group: rabbits were exposed to NOHN (0.25 Mpa) once a day for 4 days after decompression. Control group: 4 rabbits were exposed to normal air. Results (1) The labeling index (LI) of proliferation of lung mesenchymal cell in rabbits with DCS was obviously higher than that in the control group (P<0.01); (2) The LI of proliferation of lung mesenchymal cell with DCS in HBO-1 group was higher than that in HBO-4 group (P<0.05); (3) The LI of proliferation of lung mesenchymal cell in HBO group was lower than that in DCS control group or NOHN group(P<0.05). Conclusions (1) Quick decompression can cause acute lung injury with the changes of the proliferation of lung mesenchymal cell. (2) HBO can inhibit the proliferation of lung mesenchymal cell in rabbits with DCS and have an beneficial effects on structural remodeling of acute lung injury. Many times HBO treatment is better than once.
