Relationship of lipoprotein(a)with inflammatory biomarkers and cardiac damage in patients with essential hypertension
10.13431/j.cnki.immunol.j.20250070
- VernacularTitle:脂蛋白a与原发性高血压患者炎症标志物及心脏损害的关系
- Author:
Huang HUANG
1
;
Zhiyan WANG
;
Yan YANG
;
Yigeng LIU
;
Songran LI
;
Jinhuan WANG
;
Xinyuan ZHOU
;
Yang SONG
Author Information
1. 联勤保障部队第九八一医院心血管内科,河北 承德 067000
- Publication Type:Journal Article
- Keywords:
essential hypertension;
Lipoprotein(a);
C reactive protein;
neutrophil-to-lymphocyte ratio;
fibrinogen;
myocardial infarction
- From:
Immunological Journal
2025;41(7):483-488
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of lipoprotein a[Lp(a)]on the inflammatory state and cardiovascular system of patients with essential hypertension.Methods The clinical data of 234 patients with essential hypertension admitted from January 2022 to November 2023 were retrospectively collected.According to the serum Lp(a)concentration,they were divided into the normal Lp(a)group(n=185)and the high Lp(a)group(n=49).The differences in serum inflammatory markers C reactive protein(CRP),neutrophil-to-lymphocyte ratio(NLR),and fibrinogen between the two groups were compared.Pearson correlation analysis was used to analyze the correlation between Lp(a)and inflammatory markers,and the incidence of cardiac target organ damage between the two groups of patients was compared.Results Compared with the normal Lp(a)group,the CRP concentration,NLR and fibrinogen concentration of hypertensive patients in the high Lp(a)group increased(P<0.05,P<0.01),and the concentration of Lp(a)was positively correlated with CRP,NLR and fibrinogen(r=0.168,0.165,0.321,P<0.05).The incidence of myocardial infarction was higher in the high Lp(a)group[22.45%(11/49)]than in the normal Lp(a)group[7.57%(14/185)](P<0.01).Conclusion In patients with essential hypertension,high Lp(a)concentration is associated with a stronger inflammatory response,and elevated Lp(a)concentration is related to an increased incidence of myocardial infarction,suggesting that Lp(a)may affect target organ damage in patients with essential hypertension by promoting inflammation.
