Research progress of TCM regulating TLR4 signaling pathway in treat-ment of Alzheimer disease
10.3969/j.issn.1000-4718.2025.07.020
- VernacularTitle:中药靶向TLR4信号通路治疗阿尔茨海默病的研究进展
- Author:
Yuxin WANG
1
;
Qi WANG
1
;
Quan LI
1
;
Yanyan ZHOU
1
Author Information
1. 黑龙江中医药大学,黑龙江 哈尔滨 150040
- Publication Type:Journal Article
- Keywords:
Alzheimer disease;
Toll-like receptor 4;
signaling pathway;
traditional Chinese medicine
- From:
Chinese Journal of Pathophysiology
2025;41(7):1421-1427
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer disease(AD)is a neurodegenerative disorder characterized by the abnormal deposition of amyloid β-protein(Aβ).Inflammation plays a significant role in promoting this abnormal deposition.Toll-like receptor 4(TLR4)is recognized as a"primary regulator"of the inflammatory response,facilitating the activation of microglia and interacting with various pathways,including nuclear factor-κB and nucleotide-binding oligomerization domain-like recep-tor protein 3.This interaction can lead to an inflammatory cascade that accelerates the progression of AD.Numerous pro-spective studies have demonstrated that traditional Chinese medicine can modulate the TLR4 signaling pathway,effective-ly addressing both the onset and progression of AD.However,a comprehensive review of how Chinese medicine regulates this pathway in the treatment of AD is currently lacking.Therefore,this paper aims to detail the latest findings related to TLR4 in the prevention and treatment of AD,drawing from recent literature.It will explore the mediation of traditional Chinese medicine,preserving its essence,and provide references and a basis for clinical practices aimed at preventing and treating AD.
