Effects of maternal obesity on offspring ovarian function and its under-lying mechanisms
10.3969/j.issn.1000-4718.2025.07.019
- VernacularTitle:母体肥胖对子代卵巢功能的影响及其机制
- Author:
Wanyue LI
1
;
Baile WU
;
Yanyan ZHANG
;
Lijun SHI
Author Information
1. 北京体育大学运动生理学教研室,北京 100084
- Publication Type:Journal Article
- Keywords:
maternal obesity;
ovarian function;
offspring health;
follicular development;
epigenetic modification
- From:
Chinese Journal of Pathophysiology
2025;41(7):1414-1420
- CountryChina
- Language:Chinese
-
Abstract:
Maternal obesity has been shown to exert adverse transgenerational effects on offspring ovarian function,characterized by reduced ovarian follicle reserve,impaired granulosa cell function,and disrupted reproductive cycles.The underlying mechanisms involve cellular stress-induced damage characterized by mitochondrial dysfunction,oxidative stress,and apoptosis,as well as dysregulation in key regulatory pathways such as ovarian hormone secretion,gene expression,and epigenetic modifications.This review synthesizes existing evidence on how maternal obesity-induced acute stress and chronic genetic/epigenetic alterations jointly contribute to offspring ovarian impairment.The findings elu-cidate the complex relationship between maternal metabolic status and offspring reproductive health,providing a robust theoretical foundation for refining prenatal management and developing targeted intervention strategies.
