Efficacy observation of maintenance treatment of thiopurines after exclusive enteral nutrition therapy for Crohn′s disease children
10.3760/cma.j.cn101480-20210519-00040
- VernacularTitle:全肠内营养后嘌呤类药物维持治疗儿童克罗恩病的疗效观察
- Author:
Youyou LUO
1
;
Mingfang SUN
1
;
Yue LOU
1
;
Hong ZHAO
1
;
Youhong FANG
1
;
Kerong PENG
1
;
Jindan YU
1
;
Jingan LOU
1
;
Jie CHEN
1
Author Information
1. 浙江大学医学院附属儿童医院消化科 国家儿童健康与疾病临床医学研究中心，杭州 310052
- Publication Type:Journal Article
- Keywords:
Crohn′s disease;
Exclusive enteral nutrition;
Thiopurines;
Clinical remission;
Child
- From:
Chinese Journal of Inflammatory Bowel Diseases
2022;06(1):65-69
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy of maintenance treatment of thiopurines after exclusive enteral nutrition (EEN) therapy for Crohn′s disease (CD) children, and explore the influencing factors of recurrence.Methods:A retrospective case-control study was conducted. CD children treated in the Children′s Hospital of Zhejiang University School of Medicine from March 2013 to March 2021 were included retrospectively. Data before EEN were collected including general demographics, Paris classification, the pediatric Crohn′s disease activity index (PCDAI), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and serum albumin levels. According to the recurrence at 1 year of follow-up, patients were divided into remission group and recurrence group. The differences in clinical data before EEN between the 2 groups were analyzed. The factors influencing the recurrence were analyzed.Results:Thirty-five children were enrolled, including 25 (71.4%) males and 10 (28.6%) females. The age at diagnose was (11.2 ± 3.1) years old and the disease duration was 3.5 (2.2, 6.9) months. After 1 year of follow-up, 15 children had recurrence at least for one time and were divided into the recurrence group. Twenty (57.1%) children continued to maintain 6-mercaptopurine (6-MP) monotherapy and were divided into the remission group. There was no significant differences in gender, diagnostic age, and CRP, ESR, serum albumin and PCDAI before EEN between the two groups (all P>0.05). There was significant difference in the percentage of patients with disease duration of longer than 1 year before EEN between the two groups ( P = 0.026) . Conclusions:The children with the disease duration of longer than 1 year before EEN may be in high risk of recurrence on the regimen of maintenance treatment of thiopurines after EEN.
