Predictive value of serum homocysteine combined with interleukin-6 in patients with recurrent spontaneous abortion
10.16753/j.cnki.1008-2344.2025.03.010
- VernacularTitle:血清同型半胱氨酸联合白细胞介素6检测对复发性流产患者的预测价值
- Author:
Zehao HAN
1
;
Huizhong CHANG
;
Lei SUN
;
Rongdong SHI
Author Information
1. 长治医学院附属长治市人民医院检验科,山西 长治 046000
- Publication Type:Journal Article
- Keywords:
recurrent spontaneous abortion;
homocysteine;
interleukin-6
- From:
Journal of Shenyang Medical College
2025;27(3):288-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical significance and predictive efficacy of serum homocysteine(Hcy)and interleukin-6(IL-6)in women with early-pregnancy recurrent spontaneous abortion(RSA).Methods:From Aug 2021 to Aug 2024,35 women with early-pregnancy RSA were selected from Changzhi People's Hospital and designated as the RSA group,and 44 women with no history of recurrent miscarriage in early pregnancy were chosen as the control group.Enzymatic cycling assay was used to determine the serum Hcy level,and immunofluorescence assay was used to detect the serum IL-6 level.Binary logistic regression model was applied to assess the potential impact of serum Hcy and IL-6 levels on RSA.Receiver operating characteristic(ROC)curve was utilized to evaluate the diagnostic value of serum Hcy and IL-6 levels for RSA.Results:RSA group exhibited significantly higher Hcy levels(P＜0.01)and lower IL-6 levels(P＜0.01)compared to the control group.High level of serum Hcy(OR=1.628,95%CI:1.169-2.266)and low level of serum IL-6(OR=0.478,95%CI:0.289-0.791)significantly affected recurrent miscarriage(P＜0.05).ROC analysis showed AUC values of 0.765(Hcy),0.851(IL-6),and 0.919(combined),with sensitivities of 65.7%,91.4%,and 77.1%,and specificities of 86.4%,59.1%,and 100%,respectively.Conclusions:There are significant differences in the levels of serum Hcy and IL-6 between RSA patients and healthy controls.Serum Hcy combined with IL-6 detection has certain diagnostic value for predicting RSA.
