Progress on role and mechanism of SOCS3 in glycolipid metabolic diseases
10.3969/j.issn.1000-484X.2025.10.040
- VernacularTitle:SOCS3在糖脂代谢性疾病中的作用及机制研究进展
- Author:
Ruofei MEI
1
;
Zhen WANG
;
Kai FEI
;
Siyu CHEN
;
Fuliang MA
;
Quan GONG
;
Hui YANG
Author Information
1. 长江大学医学部,荆州 434020
- Publication Type:Journal Article
- Keywords:
Suppressor of cytokine signaling 3;
Glycolipid metabolic diseases;
Inflammation;
Janus kinases
- From:
Chinese Journal of Immunology
2025;41(10):2548-2553
- CountryChina
- Language:Chinese
-
Abstract:
Suppressor of cytokine signaling 3(SOCS3),a member of SOCS family,plays a major role in cell signaling trans-duction.SOCS3 is important in regulation of immune homeostasis and also involved in the control of energy metabolism,mainly through regulating JAK/STAT pathway.Recent studies have shown that SOCS3 was closely associated with glycolipid metabolic diseases like diabetes and obesity,and can be used as a new target for treatment of these glycolipid metabolic diseases.This review focuses on the latest research progress of the role and mechanism of SOCS3 in glycolipid metabolic diseases,and discusses the possibility of SOCS3 as a therapeutic target for glycolipid metabolic diseases.
