Role of neutrophil extracellular traps in organ injury after hemorrhagic shock
10.3969/j.issn.1000-484X.2025.10.039
- VernacularTitle:中性粒细胞胞外诱捕网在失血性休克器官损伤中的作用
- Author:
Guiyan JIA
1
;
Jing WANG
;
Chunyu NIU
;
Zigang ZHAO
Author Information
1. 河北北方学院基础医学院/微循环研究所,张家口 075000
- Publication Type:Journal Article
- Keywords:
Neutrophil extracellular trap;
Hemorrhagic shock;
Organ damage
- From:
Chinese Journal of Immunology
2025;41(10):2540-2547
- CountryChina
- Language:Chinese
-
Abstract:
Following hemorrhagic shock,locally released chemotactic molecules attract neutrophils to rapidly migrate to the damaged tissues,while effectively bind,engulf and kill microorganisms,along with chromatin releasing and forming a substance deco-rated with a meshwork of microbicidal proteins and enzymes,a DNA-protein structure named neutrophil extracellular traps(NETs).The formation and degradation of NETs are regulated by multiple factors,and an imbalance in the formation and degradation of NETs plays a role in cellular damage and the aggregation of inflammatory factors,which is one of the main mechanisms of uncontrolled in-flammatory response and further aggravates organ damage.Studies have shown that NETs are involved in the process of hemorrhagic shock-induced organ damage,but the relevant mechanisms have not been fully elucidated.In this paper,we review the role of NETs in organ damage after hemorrhagic shock and the related mechanisms,and in order to understand the role of NETs and provide a refer-ence for new targets for the prevention and treatment of hemorrhagic shock.
