Role,mechanism and application of IL-2 in occurrence and development of systemic lupus erythematosus
10.3969/j.issn.1000-484X.2025.10.038
- VernacularTitle:IL-2在系统性红斑狼疮发生发展中的作用、机制及应用前景
- Author:
Shumin XU
1
;
Junming LI
1
Author Information
1. 南昌大学第一附属医院检验中心,南昌 310000
- Publication Type:Journal Article
- Keywords:
Systemic lupus erythematosus;
IL-2;
Immunotherapy;
Regulatory T cells
- From:
Chinese Journal of Immunology
2025;41(10):2535-2539
- CountryChina
- Language:Chinese
-
Abstract:
IL-2 is a multifunctional cytokine whose main functions include activating and maintaining T cell survival.Re-search has shown that the level and function of IL-2 in peripheral blood of patients with systemic lupus erythematosus(SLE)have sig-nificantly decreased,and are associated with the activity of SLE disease.In recent years,the decrease in IL-2 level has been found to play a crucial role in the occurrence and development of SLE,and is one of the important mechanisms for T cell homeostasis imba-lance and immune regulation disorders in SLE patients.The low-dose IL-2 treatment regimen for SLE based on this discovery has en-tered clinical application.However,there is still considerable controversy regarding the mechanism of decreased IL-2 level and sup-pressed functions in SLE patients.Clarifying this mechanism is of great significance for further clarifying the occurrence and develop-ment mechanism of SLE and developing new treatment regimens.
