Role of axis of susceptible genes-paneth cells-intestinal microecology in inflammatory bowel disease

VernacularTitle:易感基因-潘氏细胞-肠道微生态轴在炎症性肠病中的作用
Author: Pengfei XU ¹ ; Qianhui ZHOU ; Yuhan LIAO ; Wenhan ZHUANG ; Qi ZHUANG ; Yuefang YE
Author Information

1. 杭州师范大学医学部临床医学院，杭州　311121
Publication Type:Journal Article
Keywords: Paneth cells; Inflammatory bowel disease; Intestinal microbiota; Susceptible genes
From: Chinese Journal of Inflammatory Bowel Diseases 2022;06(1):83-86
CountryChina
Language:Chinese
Abstract: Inflammatory bowel disease (IBD) is a disorder of immune and microbial dysregulation, induced by environmental factors in a genetically predisposed individual. Studies on IBD-associated genes have demonstrated that Paneth cells (PC) are central to the pathogenesis of IBD, especially in the development of Crohn′s disease (CD). The morphology, quantity and function of PC are easily affected by susceptible genes. In the intestine, PC participate in the formation of stem cell niche and secrete antimicrobial particles, which plays a vital role in regulating intestinal microbiota and maintaining intestinal mucosal homeostasis. Meanwhile, the proliferation and maturation of PC are also dependent on the symbiotic microbiota in the intestine. This review focuses on the interaction of susceptible genes, PC and intestinal microbiota, as well as their influence on the occurrence and development of IBD.