Comparison of Safety Between Cat Dander Cluster and Conventional Immunotherapy and Analysis of Factors Affecting Adverse Reactions
10.11969/j.issn.1673-548X.2025.06.010
- VernacularTitle:猫皮屑集群与常规免疫治疗安全性比较及不良反应影响因素分析
- Author:
Yi RU
1
;
Lisha LI
1
;
Kai GUAN
1
Author Information
1. 100730 中国医学科学院/北京协和医学院北京协和医院变态反应科、过敏性疾病精准诊疗研究北京市重点实验室、国家皮肤与免疫疾病临床医学研究中心、协和转化医学中心
- Publication Type:Journal Article
- Keywords:
Cat dander;
Allergic rhinitis;
Allergic asthma;
Allergen-specific immunotherapy;
Safety
- From:
Journal of Medical Research
2025;54(6):49-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the safety of cluster immunotherapy versus conventional immunotherapy for cat dander-induced rhinitis,with or without asthma,and to explore the main influencing factors for the occurrence of adverse reactions.Methods Patients with cat dander-induced rhinitis with or without asthma were recruited.Patients were divided into cluster immunotherapy group(cluster group)and conventional immunotherapy group(conventional group).The incidence of adverse reactions in both groups was compared based on individual patients and the number of injections(dose escalation phase),and influencing factors for the occurrence of adverse reactions were analyzed based on the patients' baseline information prior to treatment.Results A total of 78 patients were enrolled,with 45 in the cluster group and 33 in the conventional group.There was no statistically significant difference in the per-patient incidence of local(P=0.648)and systemic(P=1.000)adverse reactions between the two groups.The size of local reactions(P=0.321)also showed no significant difference.When the number of injections was considered during the dose escalation phase,no significant difference was observed in the per-shot incidence of local(P=0.705)and systemic adverse reactions(P=0.237)between the two groups.Pre-treatment levels of T-IgE(OR=1.001,95％CI:1.000-1.003,P=0.032),sIgE/T-IgE(％)(OR=1.079,95％CI:1.003-1.161,P=0.042),medication score(OR=1.338,95％CI:1.055-1.696,P=0.016),and symptom and medication score(OR=1.217,95％CI:1.028-1.440,P=0.022)were independent risk factors for the occurrence of local adverse reactions.Asthma patients had a 16.393-fold higher risk of systemic adverse reactions compared to non-asthma patients(OR=16.393,95％CI:1.076-249.752,P=0.044).Conclusion There were no significant differences in the per-patient or per-shot incidence of local or systemic adverse reactions between the cluster group and conventional group.Higher pre-treatment levels of T-IgE,sIgE/T-IgE,medication score,and symptom and medication score should alert clinicians to the risk of local adverse reactions,while asthma patients should be mo-nitored for the potential occurrence of systemic adverse reactions.
