Mesalamine-associated red-brown urine discoloration: a case report
10.3760/cma.j.cn101480-20200529-00059
- VernacularTitle:美沙拉嗪相关红棕色尿色异常一例
- Author:
Kunyu ZHENG
1
;
Yue LI
;
Yingzhen GU
;
Yaozheng YANG
;
Huijun SHU
;
Lingyan ZUO
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院内科，北京 100730
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Mesalamine;
N-acetyl-5-ASA;
Hypochlorite;
Urine discoloration
- From:
Chinese Journal of Inflammatory Bowel Diseases
2021;05(2):187-188
- CountryChina
- Language:Chinese
-
Abstract:
Mesalamine (5-aminosalicylic acid, 5-ASA) is used for ulcerative colitis, mild Crohn′s disease. The orally taken mesalamine is excreted primarily as N-acetyl-5-aminosalicylic acid (N-acetyl-5-ASA) via urine, renal damage and hematuria are rare. However, red-brown urine discoloration has been noted by some patients, which is associated with the reaction between N-acetyl-5-ASA and remaining hypochlorite in the disinfectant-containing water. This article reports a case of mesalamine-associated red-brown urine discoloration and reviews related literatures.
